عرض تفاصيل البحث

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عنوان البحث
Investigation Of The Relationship Between Polymorphism Of Mthfr Gene & Male Infertility In Some People At Thi – Qar Province
عنوان المجلة
Journal Of Natural Science, Biology And Medicine
ISSN-2770-4491
تفاصيل النشر
سنة النشر - 2024 / الفهرس الاصلي للمجلة - 15 : 1 (عدد الصفحات 6)
تصنيف البحث
مناعة طبية - المجموعة العلمية
رابط DOI
#
رابط البحث
فتح في موقع المجلة الرسمي
البحث والاستدامة
الهدف 4 – التعليم الجيد   المزيد حول هذا الهدف
البحث والمجتمع
نعم , يدعم
الكلمات المفتاحية
MTHFR, polymorphism, Infertility, RFLP, PCR

اسم الباحثجهة الانتساببلد الباحث
احلام محسن خضير جامعة سومر العراق
عبد الجليل عزيز جامعة سومر العراق

Background: The gene known as methylenetetrahydrofolate reductase (MTHFR) is control of the production and methylation of deoxynucleic acids. Male infertility has been linked to the MTHFR polymorphism (C677T). Objective: a current study on male infertility was carried out to ascertain whether the MTHFR polymorphism (C677T) is connected to male infertility. The study included 30 male infertility patients aged between (26-58) years and 20 individual healthy control groups. The studied ages were distributed into three groups. The major group was (26 – 36) years, and the percentage was (40%). The second group was (37 – 47) years, and the rate was (26.67 %); the third group was (48 – 58) years, with a percentage (of 33.33%). The last group is the most prevalent among the three groups. Method: DNA was isolated, and Restriction Fragment Length Polymorphism – Polymerase Chain Reaction (RFLP-PCR) was done by using specific primers to the MTHFR gene. Results: the results indicated to the presence of mutations in 15 out of 30 patients after using restriction enzymes Hinf. Statistical analysis showed a correlation between male infertility and the emergence of MTHFR C677T gene mutation paralleled through the control group. Conclusion: When we compared the patient’s group and the healthy group, we established there is a correlation between MTHFR C677T gene polymorphism and the incidence of male infertility in our study population.
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